Research progress in sinomenine structural modification
10.3969/j.issn.1006-0111.2018.03.003
- VernacularTitle:青藤碱结构改造的研究进展
- Author:
Xiuzheng LI
1
;
Qingjie ZHAO
;
Jiaxiao DONG
;
Yunyun JIANG
;
Guangming YE
Author Information
1. 安徽医科大学解放军98临床学院
- Keywords:
sinomenine;
structural modification;
derivatives
- From:
Journal of Pharmaceutical Practice
2018;36(3):204-209,214
- CountryChina
- Language:Chinese
-
Abstract:
Sinomenine is an alkaloid found in the climbing plant Sinomenium acutum.Structurally,it belongs to the iso-quinoline derivatives,which have various bioactivities.Clinically,it is used in the treatment for rheumatism,rheumatoid arthri-tis and arrhythmia,etc.Nevertheless,due to the need of large dose,photo and thermal instability,quick metabolism in vivo and highly allergic for some patients,scientists have committed to modify its structure to develop the highly effective and low toxic derivatives.In this paper,the recent advances in structural modification of sinomenine are reviewed.