Research progress in depression related biomarkers based on omics technology
10.3969/j.issn.1006-0111.2018.03.002
- VernacularTitle:基于组学技术的抑郁症相关生物标志物研究进展
- Author:
Shiyu LIU
1
;
Liang ZHAO
;
Jun CHEN
;
Guoqing ZHANG
Author Information
1. 第二军医大学第三附属医院药剂科
- Keywords:
depression;
genomics;
biomarker;
transcriptomics;
proteomics;
metabolomics
- From:
Journal of Pharmaceutical Practice
2018;36(3):198-203
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the incidences of depression increased year by year due to increased social pressure,which do serious harm to human being both physically and mentally.Studies have shown that the pathogenesis of depression is complicat-ed,mainly related to body′s inflammation,neurotrophic and metabolic processes.There were no sufficient objective bases for the clinical diagnosis of depression.The drug treatment result was not satisfactory.Therefore,biomarkers become more and more important in disease risk prediction,classification,diagnosis and prognosis.The rapid developments in genomics,transcriptom-ics,proteomics,metabolomics and their applications in the diagnosis make it possible to further screen for depression related bio-markers.This article reviewed the research progresses in depression related biomarkers with omics technologies.
