Crystal structure and optical activity of 2-(3,4-dimethoxyphenyl)-4-oxo-4H-chromen-3-yl acetate
10.3969/j.issn.1006-0111.2018.02.015
- VernacularTitle:2-(3,4-二甲氧基苯基)-4-氧代-4H-色烯-3-基乙酸酯的晶体结构及旋光性
- Author:
Kaixia ZHANG
1
;
Chaoming WANG
;
Yongsheng JIN
Author Information
1. 烟台大学新型制剂与生物技术药物研究山东省高校协同创新中心、教育部分子药理和药物评价重点实验室
- Keywords:
flavonoids;
X-ray single crystal diffraction;
optical activity
- From:
Journal of Pharmaceutical Practice
2018;36(2):170-172,179
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the structure and optical activity of flavonoid derivative:2-(3,4-dimethoxyphenyl)-4-oxo-4 H-chromen-3-yl acetate(4).Methods The absolute configuration was obtained by X-ray single crystal diffraction.The optical rotation of the compound was determined by the SGW ?R-1 automatic polarimeter.Results X-ray single crystal diffrac-tion showed that compound 4 belongs to the orthorhombic space group P212121with a=7.763(2)?A,b=13.930(4)?A and c=14.906(4),α= β= γ=90.00°,V =1611.91(8)?A3,Z=8.There is no hydrogen bonding between the molecules in this crystal state.The molecules maintain their stable arrangement in space by van der Waals forces.It can be seen from the single-crystal data that there is a 33.9(2)° torsion of the dimethoxy-substituted benzene ring in the compound 4 with respect to the 4 H-chromene skeleton,suggesting that there may exist optical activity.Further experimental results of the optical rotation proved that the compound has a L-rotatory,specific rotation[α]19.1D = -5.077°.Conclusion The results of the single crystal indicated that the benzene ring substituted with dimethoxy group in compound 4 has a 33.9(2)° torsion relative to the 4 H-chromene skeleton,which results in chirality and optical activity.This is the first report that non-flavonoid-glycoside has optical activity.
