Evaluation of hypoglycemic drug-drug interactions by software
10.3969/j.issn.1006-0111.2018.02.014
- VernacularTitle:基于药物相互作用软件评价降糖药物的相互作用
- Author:
Fanghong SHI
1
;
Hao LI
;
Xiaoyan LIU
;
Zaili ZHANG
Author Information
1. 上海交通大学医学院附属仁济医院药学部
- Keywords:
hypoglycemic drugs;
drug-drug interactions(DDI);
evaluation by software
- From:
Journal of Pharmaceutical Practice
2018;36(2):166-169
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate and analyze the drug-drug interactions(DDI)of different antidiabetic drugs.Methods DDI database Lexi-InteractionTMwas used to evaluate DDI for 28 commonly used antidiabetic medications(including insulin and 27 non-insulin preparations).Results 882 DDIs were identified for 28 drugs.Category C was the top rated DDI(69.8%). Category C,D,X were accounted for 91.2% of the total DDI.28 medication combinations belonged to category X,which should be avoided to use together.Sulfonylureas had the most DDI,followed by metformin.Alpha-glucosidase inhibitors had least DDI.Conclusion Hypoglycemic drugs with less DDI,such as α-glycosidase inhibitors,glucagon-likepeptide1(GLP-1)an-alogs and sodium-dependent glucose transporters 2 inhibitor(SGLT2i)should be considered with high priority for patients tak-ing multiple antidiabetic medications,elderly patients and patients with liver-kidney dysfunction.
