Meta-analysis on renal toxicity of vancomycin given by continuous infusion vs in-termittent infusion
10.3969/j.issn.1006-0111.2018.02.009
- VernacularTitle:比较万古霉素持续输注与间断输注引起肾毒性的荟萃分析
- Author:
Lili ZHENG
1
;
Yuanhuan XUAN
;
Qian JIANG
;
Fangfang FAN
;
Li YAO
;
Shengjun ZHAO
Author Information
1. 新疆医科大学附属中医医院药学部
- Keywords:
vancomycin;
continuous infusion;
intermittent infusion;
renal toxicity;
Meta-analysis
- From:
Journal of Pharmaceutical Practice
2018;36(2):136-139,146
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the renal toxicity of vancomycin with continuous infusion vs intermittent infusion. Methods The databases of EMBASE,PUBMED,the Cochrane Register of Controlled Trials,CBM,CNKI and WanFang were searched.The Cochrane Revman5.2 software was used for Meta-analysis.Results Two RCTs and eight observational studies were included in the systematic literature search with total of 1 764 patients.1 037 patients received vancomycin with continuous infusion while 727 patients with intermittent infusion.The Meta-analysis indicated that there was no significant difference in renal toxicity between continuous infusion group and intermittent infusion group(P>0.05).Conclusion Vanco-mycin continuous infusion cannot effectively reduce the incidence of renal toxicity.
