Clinical application and research progress of apatinib in cancer treatment
10.3969/j.issn.1006-0111.2018.02.002
- VernacularTitle:阿帕替尼在恶性肿瘤治疗中的临床应用与研究进展
- Author:
Xiaobin GONG
1
;
Shiyi LIU
;
Tianyi XIA
;
Hua WEI
;
Wansheng CHEN
Author Information
1. 第二军医大学附属长征医院药材科
- Keywords:
apatinib;
VEGFR2;
targeted therapy
- From:
Journal of Pharmaceutical Practice
2018;36(2):103-107,130
- CountryChina
- Language:Chinese
-
Abstract:
Antiangiogenic target therapy has been a hot topic in cancer treatment recently.Apatinib is a category 1.1 new medication developed domestically.It effectively inhibits angiogenic and exhibits promising anti-tumor activity in preclinical studies.Apatinib has been successfully applied in clinical trials of multiple malignancies,such as gastric cancer,lung cancer and breast cancer with satisfactory safety and efficacy profile.However,its mechanism of action is still not fully understood. Further researches should be carried on to improve its safety,effectiveness and marketability.This review summarized the mechanism of action,pharmacokinetics,clinical efficacy,safety and biomarkers,discussed the recent progress,hot issues and clinical prospects of apatinib,
