Chemical constituents from the marine sponge Theonella swinhoei

VernacularTitle:西沙群岛隋氏蒂壳海绵Theonella swinhoei的化学成分研究
Author: Yanyun LI ¹ ; Bin XU ; Chunwei CHENG ; Houwen LIN ; Fan YANG
Author Information

1. 上海交通大学医学院附属仁济医院药学部
Keywords: Theonella swinhoei; marine sponge; chemical constituents; structure identification
From: Journal of Pharmaceutical Practice 2018;36(1):55-60
CountryChina
Language:Chinese
Abstract: Objective To investigate the chemical constituents of the marine sponge Theonella swinhoei collected from the Xisha Islands in the South China Sea .Methods The petroleum ether and dichloromethane extract of the marine sponge T . swinhoei were purified by solvent extraction and chromatographic methods including vacuum liquid chromatography (VLC) , medium pressureliquidchromatography(MPLC),thinlayerchromatography(TLC)onsilicagel,highperformanceliquidchro-matography(HPLC) ,and Sephadex LH-20 .The chemical structures were determined by spectroscopic analysis and comparison with the reported data .Results Eight compounds were isolated and their structures were determined as cholest-7-ene-3β,5α, 6β-triol (1) ,ergosta-7 ,22-diene-3β,5α,6β-triol (2) ,25-norcycloartane-3β,6α,16β,24-tetraol (3) ,sinuflexibilin D (4) ,14-de-oxycrassin (5) ,N-(2-phenylethyl)-(9Z)-tetradecanamide(6) ,N-(2-phenylethyl)-tetradecanamide (7) ,7 ,8-dimethyl-isoallox-azine (8) .Conclusion Compounds 1～ 7 were isolated from the sponge of genus Theonella for the first time .