Advances in the studies of core-shell-type lipid-polymer hybrid nanoparticles
10.3969/j.issn.1006-0111.2018.01.003
- VernacularTitle:核-壳结构的脂质-聚合物杂化纳米粒的研究进展
- Author:
Dan LIU
1
;
Jundong ZHANG
;
Yunfei LIAN
;
Qiuyu FANG
;
Juan LI
Author Information
1. 中国药科大学药学院
- Keywords:
core-shell structure;
lipid-polymer hybrid nanoparticles;
drug delivery system;
tumor targeted
- From:
Journal of Pharmaceutical Practice
2018;36(1):13-17
- CountryChina
- Language:Chinese
-
Abstract:
Core-shell-type lipid-polymer hybrid nanoparticles (CSLPHNs) are composed by a biodegradable polymeric core coated with single or multiple layers of biomimetic lipids ,which combine the benefits of polymeric nanoparticles and lipo-somes .CSLPHNs have the advantages of small particle size ,high drug loading ,good biocompatibility and controlled release capability .It has wide applications as a novel drug delivery system .This review gives a brief introduction in characteristics , preparation methods and applications of CSLPHNs ,specifically summarizes the developments in the fields of ophthalmic drug delivery ,tumor therapy and medical diagnostic imaging .
