Practice of pharmacy consultation on dosage regimen for pediatric epilepsy patient with PPK model
10.3969/j.issn.1006-0111.2017.06.019
- VernacularTitle:应用群体药动学模型制订患儿抗癫痫给药方案的药学会诊实践
- Author:
Yanping LI
1
;
Zhouliang SUN
;
Weiwei LIN
Author Information
1. 厦门大学附属第一医院药学部
- Keywords:
population pharmacokinetics;
carbamazepine;
valproic acid;
epilepsy
- From:
Journal of Pharmaceutical Practice
2017;35(6):559-561
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to provide a reference for optimizing the dosage regimen of carbamazepine and valproate in pediatric epilepsy patients .Methods Pharmacist consulted one pediatric epilepsy patient with traumatic brain injury for post operation epilepsy treatments .The abnormal plasma concentration of carbamazepine and valproic acid was analyzed with the population pharmacokinetic (PPK) model built by this team .New medication regimen was proposed and the predictive capabili-ty of this model was evaluated .Results Seizures in this patient have been effectively controlled .Conclusion Pharmacist can optimize the antiepileptic drug treatment with PPK model and achieve rational drug use clinically .
