Research progress on in vitro lipolysis model for the evaluation of lipid formula-tions
10.3969/j.issn.1006-0111.2017.06.001
- VernacularTitle:体外脂解模型在脂质制剂评价中的研究进展
- Author:
Huiyi WU
1
;
Xiaoying LONG
Author Information
1. 南方医科大学南方医院药剂科
- Keywords:
lipolysis model;
lipid formulation;
gastrointestinal;
in vivo-in vitro correlation
- From:
Journal of Pharmaceutical Practice
2017;35(6):481-484,489
- CountryChina
- Language:Chinese
-
Abstract:
In vitro lipolysis model has become a new and promising technique to screen and evaluate oral lipid formula-tions .This model mimics the gastrointestinal tract environment and well reflects the fate of lipid formulations in GI tract after oral administration .This review summarizes the characteristics of lipid formulations ,process of gastrointestinal digestion ,ap-plications of in vitro lipolysis model and methods for the characterization of the lipolysis process ,which provides the basis for the research of oral absorption mechanism and in vivo-in vitro correlations of lipid formulations with lipolysis model .
