Study on the use of antimicrobial agents in hospitalized trauma patients based on medical big data
10.3969/j.issn.1006-0111.2017.05.021
- VernacularTitle:基于医疗大数据的创伤住院患者抗菌药物使用研究
- Author:
Guoquan SUN
1
;
Lixin SHU
;
Xiaojuan WANG
;
Shengxin CHEN
;
Zhangwei YANG
;
Jiewei LI
Author Information
1. 新疆军区药品仪器检验所
- Keywords:
trauma score;
medical big data;
antibacterial drugs;
drug use
- From:
Journal of Pharmaceutical Practice
2017;35(5):466-471
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the trauma severity and the usage of antibacterial drugs and to provide reference for standard protocol of proper antibiotic use in wound care.Methods ICD-10 and AIS were used to set up the relationship and to analyze the use of antibiotics in patients with different trauma score.Results 25 035 trauma patients were enrolled in this study.Those patients were divided into five groups according to the AIS score with least severe as group 1 to most severe as group 5.The patient percentage in group 1 to 5 was 21.92％,67.73％,8.86％,0.97％ and 0.52％ respectively.The five most frequently used antibiotic classes are second generation cephalosporins,third generation cephalosporins,first generation cephalosporins,fluoroquinolones and penicillin/beta lactamase inhibitor combination, accounted for 29.69％,22.57％,20.33％,4.66％ and 4.47％ of total DDDs of antibacterial drugs.Individually, the top 10 antibiotics are cefuroxime (12.21％), cefazolin (8.31％), ceftriaxone (7.74％), cefathiamidine (7.34％), cefotiam (4.87％), ceftazidime (3.68％), amoxicillin/clavulanic acid (3.63％), levofloxacin (3.59％), cefoxitin (3.56％), flucloxacillin (3.52％);gentamicin (2.27％), ornidazole (2.00％) and cefoperazone/tazobactam (1.44％) were used most in their categories respectively.The variety and quantity of antibacterial drugs used for different trauma patients were different.Conclusion The trauma score based on ICD-AIS can reflect the severity of trauma.The use of antibiotics in patients with different trauma score can provide reference for the clinical applications of antibiotics in wound care.
