Optimization of the preparation process for echinacoside in Herba Cistanche enteric microspheres by response surface methodology
10.3969/j.issn.1006-0111.2017.05.006
- VernacularTitle:响应面法优化肉苁蓉松果菊苷肠溶微球的制备
- Author:
Cuiying QIN
1
;
Rongli LI
;
Yunjing LI
;
Rencai CHEN
;
Jing HAN
Author Information
1. 沈阳药科大学
- Keywords:
Herba Cistanche;
response surface methodology;
sodium alginate;
ion gelatin-oven drying method;
microspheres
- From:
Journal of Pharmaceutical Practice
2017;35(5):411-414,432
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare Herba Cistanche enteric release microspheres, optimize the preparation process and study the releasing characteristics of microspheres in vitro.Methods Ion gelatin-oven drying method was used to prepare Herba Cistanche enteric microspheres.The preparation process was optimized with the aid of a Box-Behnken design.Results The optimal preparation condition was 36.33 mg/ml of sodium alginate, 10.82 mg/ml of calcium chloride and 10.93 mg/ml of chitosan.Conclusion This technology is repeatable and feasible.The microspheres have high entrapment efficiency and good sustained release characteristics.
