Recent research progress on anti-microtubule agents targeting multi-drug resistant cancers
10.3969/j.issn.1006-0111.2017.05.001
- VernacularTitle:抗肿瘤多药耐药微管蛋白调节剂的研究进展
- Author:
Saijian SHI
1
;
Wen ZHANG
;
Tingyou LI
;
Chunlin ZHUANG
Author Information
1. 南京医科大学药学院药物化学系
- Keywords:
anti-cancer;
multidrug resistant;
tubulin;
modulator
- From:
Journal of Pharmaceutical Practice
2017;35(5):385-393,397
- CountryChina
- Language:Chinese
-
Abstract:
In 2015, more than 8 million people died from various kinds of cancers all over the world.Although traditional chemotherapeutic drugs are widely used in clinic, more than 50％ of cancers are significantly resistant to traditional chemotherapeutic drugs.Tubulin targeting agents have been confirmed to be effective anti-cancer drugs in clinic.However, some anti-microtubule agents developed resistance after long-term use, such as paclitaxel and vinblastine.In recent years, it is reported that tubulin modulators targeting on the colchicine-binding site are extremely effective against multi-drug resistant cancer cells.In this article, different anti-microtubule agents targeting multi-drug resistant cancers are reviewed.
