Preparation and quality control of diosmin suppository
10.3969/j.issn.1006-0111.2017.04.009
- VernacularTitle:地奥司明栓剂的制备及质量控制研究
- Author:
Chenxiang WANG
1
;
Aifang HUANG
;
Hui JIN
;
Bin ZHOU
;
Ziye ZHOU
Author Information
1. 温州医科大学附属第一医院药学部
- Keywords:
diosmin;
suppository;
preparation;
quality evaluation
- From:
Journal of Pharmaceutical Practice
2017;35(4):325-327,349
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare diosmin suppository and establish a method for its quality control.Methods Diosmin was used as active ingredient.Polyethylene glycol 6000, polyethylene glycol 400 and glycerol were chosen as substrates.Fusion method was applied to prepare the diosmin suppository.The appearance, content uniformity, weight variation and melting time of suppository were evaluated.Results The diosmin suppository has brown color with good hardness at room temperature.The content uniformity, weight variation, melting time and dissolution rate meet the requirements of quality control.Conclusion The diosmin suppository prepared by this method was satisfied the quality requirements of suppository and serves as a new formulation of diosmin.
