Chemical constituents from Spongia sp., a marine sponge in Xisha Islands

VernacularTitle:中国西沙群岛沐浴海绵的化学成分研究
Author: Yuan TIAN ¹ ; Bin XU ; Jingfeng WANG ; Houwen LIN ; Lianjuan YANG ; Fan YANG
Author Information

1. 集美大学食品与生物工程学院
Keywords: Spongia sp.; chemical constituents; sequiterpene quinone; antifungal activity
From: Journal of Pharmaceutical Practice 2017;35(4):315-320,382
CountryChina
Language:Chinese
Abstract: Objective To investigate the chemical constituents in the marine sponge, Spongia sp., collected from the Xisha Islands.Methods The pure chemical components from the petroleum ether extract of Spongia sp.were obtained by repeated column chromatography on silica gel,ODS,Sephadex LH-20 and semi-preparative HPLC.Their structures were determined by spectroscopic analysis and comparison with the reported data.The antifungal activity of those compounds was evaluated by dilution method.Results 9 compounds were isolated and identified,including smenodiol(1),smenospongorine(2),5-epi-smenospongorine(3),dictyoceratin C(4),epi-smenospongidine(5),dictyoceratin A(6),stigmasta-4,6,8(14),22-tetraen-3-one(7),3-oxo-4,6,8(14)-triunsaturated steroids(8),ergosta-4,6,8(14),22-tetraen-3-one(9).Conclusion Compounds 1~9 were isolated from the sponge of genus spongia for the first time.Compound 2、3、5 and 9 exhibited antifungal activities against Candida albicans,Trichophyton mentaqrophytes and Trichophyton rubrum with the MIC values of 12.5~25 μg/ml.