Development process and clinic applications of antibody
10.3969/j.issn.1006-0111.2017.04.004
- VernacularTitle:抗体的发展过程及临床应用
- Author:
Yi QU
1
;
Zhiyong LI
;
Chaoyu MIAO
Author Information
1. 第二军医大学药学院药理学教研室
- Keywords:
monoclonal antibody;
genetic engineering;
clinic application
- From:
Journal of Pharmaceutical Practice
2017;35(4):301-303,333
- CountryChina
- Language:Chinese
-
Abstract:
Monoclonal antibodies have become an important part of biotechnology and pharmaceutical industry.Currently chimeric antibody, humanized antibody and fully human antibody are generally prepared by genetic engineering.With constant improvement in the antibody preparation technology, the antibody applications are rapidly increasing, especially in the development of antibody medications.In recent years, there have been many significant antibody drugs (such as PD-1 antibody, IL-17 antibody, IL-5 antibody, PCSK9 antibody) for the treatment of various diseases and solved a number of clinical problems.In modern medicine, monoclonal antibodies have become effective diagnostic and therapeutic tools.This article is a brief review of the recent antibody development process, clinic applications and significant antibody drugs approved by FDA.
