New strategy for cardio-cerebrovascular diseases: baroreflex activation therapy
10.3969/j.issn.1006-0111.2017.04.002
- VernacularTitle:心脑血管疾病的治疗新策略:激活压力感受性反射
- Author:
Lili ZHANG
1
;
Aijun LIU
;
Lei CHEN
;
Hongtao SONG
Author Information
1. 福州总医院药学科
- Keywords:
baroreflex activation therapy;
cardio-cerebrovascular diseases;
mechanism
- From:
Journal of Pharmaceutical Practice
2017;35(4):294-297,345
- CountryChina
- Language:Chinese
-
Abstract:
The incident number and death toll of cardio-cerebrovascular diseases increase continuously in China.The impairment of arterial baroreflex (ABR) is closely related to the genesis and development of cardio-cerebrovascular diseases (such as hypertension and chronic heart failure).Barostim neoTM (by American CRVx.Inc) can reduce blood pressure and heart rate by electrically stimulating carotid sinus baroreceptors and activating baroreflex.Therefore, it can be used to treat resistant hypertension, heart failure and end-stage renal disease, etc.The mechanism of baroreflex activation therapy (BAT) includes inhibiting sympathetic nervous system and rennin-angiotensin system, and increasing the activity of vagus nerve.Thus it improves baroreflex sensitivity and heart rate variability, and restores the structure and function of key organs.
