Advance in resistance mechanism of cancer stem cells therapy
10.3969/j.issn.1006-0111.2017.03.001
- VernacularTitle:肿瘤干细胞的治疗耐受机制研究进展
- Author:
Mengxue CAO
1
;
Fan SUN
;
Houwen LIN
Author Information
1. 上海中医药大学中药学院
- Keywords:
cancer stem cells;
therapy resistance;
ABC transports;
ALDH;
DNA damage repair;
developmental pathway activation
- From:
Journal of Pharmaceutical Practice
2017;35(3):193-196,247
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is the leading cause of cancer deaths worldwide.Recurrence and metastasis are the primary reasons for its poor prognosis.Growing evidence has proposed that lung cancer may be driven by cancer stem cells (CSCs), which may be responsible for the poor outcome of lung cancer.The resistance mechanisms of cancer stem cells include four aspects: high expression of the chemo-resistant efflux transporter ABC in CSCs populations, over-expression of ALDH, efficient DNA damage repair system, developmental pathway activation.The tolerance mechanism of CSCs was described to provide theoretical basis for clinical treatment and development of new anti-tumor drugs.
