Determination of amlodipine and telmisartan in the compound tablet by first de-rivative UV spectrophotometry
10.3969/j.issn.1006-0111.2017.02.013
- VernacularTitle:用紫外导数分光光度法测定复方替米沙坦氨氯地平片的含量
- Author:
Jiangtao SU
1
;
Changjie HU
;
Hanqiao ZHANG
;
Menglin ZHANG
;
Weihong XIE
;
Zhiyuan MI
Author Information
1. 湖北工业大学生物工程与食品学院
- Keywords:
first derivative UV spectrophotometry;
telmisartan;
amlodipine;
assay
- From:
Journal of Pharmaceutical Practice
2017;35(2):150-153
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine telmisartan and amlodipine assay in the compound tablet .Methods First derivative UV spectrophotometry was used at wavelength 236 nm for telmisartan and 390 nm for amlodipine .Results Telmisartan con-tent has a good linear relationship in the concentration range of (4~20) × 10-3 mg/ml .The standard curve equation is Y =0 .0043 X-0 .0005 and correlation coefficient R2 =0 .9993 .Amlodipine content has a good linear relationship in the concen-tration range of (10~90) × 10-3 mg/ml .The standard curve equation is Y =0 .0003 X+0 .0002 and correlation coefficient R2 =0 .9995 .Conclusion The assay results from this method are consistent with the results from HPLC .This procedure pro-vides a specific ,accurate and precise method to assay the amlodipine and telmisartan in compound tablet .
