Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states
10.3969/j.issn.1006-0111.2017.02.003
- VernacularTitle:基于疾病动物模型的中药药动学研究进展
- Author:
Yun WANG
1
;
Yifeng CHAI
;
Zhenyu ZHU
Author Information
1. 第二军医大学药学院药物分析学教研室
- Keywords:
pathological state;
animal model;
pharmacokinetics;
modernization of traditional Chinese medicine
- From:
Journal of Pharmaceutical Practice
2017;35(2):108-111,140
- CountryChina
- Language:Chinese
-
Abstract:
In recent years ,pharmacokinetics of traditional Chinese medicine has become essential for the modernization of traditional Chinese medicine .Pharmacokinetics is an important means for connecting traditional Chinese medicine with west-ern medicine .Medications exert efficacy only when there is sufficient concentration at the target sites .The drug concentration is not only related to the dosage ,but is also closely correlated to the metabolic processes in human body .Most pharmacokinetic studies of traditional Chinese medicine are based on healthy animals ,which ignore significant changes of pharmacokinetic pa-rameters in the diseased state .In this paper ,the comparative pharmacokinetics of the traditional Chinese medicine based on ani-mal models in their diseased states was reviewed .Developmental trends of pharmacokinetics of traditional Chinese medicine with different animal models were also discussed .
