Study on the micelle properties of montelukast sodium in aqueous solution
10.3969/j.issn.1006-0111.2017.01.009
- VernacularTitle:孟鲁司特钠水溶液的胶束性质研究
- Author:
Han YAN
1
;
Yueying HUANG
;
Yiwei SHEN
;
Xiaoqing SHI
;
Jun BIAN
Author Information
1. 解放军411医院药学科
- Keywords:
montelukast sodium;
surface active;
CMC;
absorbance;
transmittance;
stability
- From:
Journal of Pharmaceutical Practice
2017;35(1):36-38,66
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the physicochemical properties of aqueous solution of surface active drug montelukast so-dium (MS) ,which could provide experimental basis for further development of micelle or mixed micelle preparations .Methods Critical micelle concentration (CMC) of MS at different temperatures were determined by conductivity measurements .The absorbance and transmittance of MS aqueous solution were measured by UV at different sodium chloride concentration levels . The micelle stability was evaluated via high speed centrifugal .Results The CMC of MS aqueous solution at 25℃ ,30℃ ,35℃were 0 .75 ,0 .82 ,0 .90 mmol/L .The absorbance and transmittance of MS aqueous solution were affected by the sodium chlo-ride concentration and the concentration of MS itself .It was observed that a clear solution was obtained when MS concentration>7 .5 mmol/L and no precipitation was noticed even after high speed centrifugal .Conclusion Montelukast sodium is a surface active drug .Its solubility is related to MS concentration .The solubility is also sensitive to the temperature and the electrolyte concentration .These unique physicochemical properties could be used to develop micelle or mixed micelle pharmaceutical prepa-rations .
