Preparation of micronized nimodipine push-pull osmotic pump tablets

VernacularTitle:尼莫地平微粉化物双层渗透泵控释片的制备
Author: Liqing CHAI ¹ ; Airong YAN
Author Information

1. 山西省人民医院药学部
Keywords: nimodipine; micronization; push-pull osmotic pump tablets; release; factor f2
From: Journal of Pharmaceutical Practice 2017;35(1):31-35
CountryChina
Language:Chinese
Abstract: Objective To prepare micronized nimodipine push-pull osmotic pump (PPOP) controlled release tablets . Methods The nimodipine as a model drug ,micronization technique was applied to the PPOP method .Designed and prepared the controlled release of the nimodipine tablet for 12 hours in vitro .The factor f2 was used to evaluate the similarities of differ-ent dissolution profiles ,and the optimal formulation was performed .Results The micronized nimodipine PPOP controlled re-lease tablets were successfully prepared with excellent zero-order release characteristics .The PPOP tablet′s release behavior was close to the zero-order release equation (r= 0 .998 4) .Conclusions The controlled-release formulation was prepared suc-cessfully .Micronized technique combined with the PPOP method significantly increased the release of the nimodipine tablet , the poorly soluble drug ,in vitro .