Clinical effects of continuous sequential therapy of femoston in 121 cases of meno-pausal syndrome
10.3969/j.issn.1006-0111.2016.06.019
- VernacularTitle:芬吗通连续序贯治疗121例更年期综合征临床疗效的观察
- Author:
Huiping LOU
1
;
Suping CHAI
;
Min WANG
Author Information
1. 宁波市宁海县妇幼保健院
- Keywords:
femoston;
hormone replacement therapy;
menopausal syndrome
- From:
Journal of Pharmaceutical Practice
2016;34(6):560-562
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy and safety of continuous sequential hormone replacement therapy of femoston for menopausal syndrome .Methods 121 cases of menopausal syndrome at expert outpatient service in our hospital from January 2014 to October 2015 received hormone replacement therapy of femoston for 24 weeks .Before and after treat-ment ,Kupperman score ,blood follicle stimulating hormone (FSH) ,estradiol (E2 ) ,luteinizing hormone (LH) and endometri-al thickness were determined .Results With the prolonging of treatment time ,patient's menopausal symptoms gradually re-lieved .Kupperman scores were declining .After 6 courses of treatment ,patient's menopausal symptoms completely eased . Kupperman scores decreased by 95 .0% (P<0 .01) ,serum FSH and LH decreased significantly (P<0.05 and P<0 .01) and serum E2 increased notably (P<0 .01) without endometrial thickness changes (P>0.05) .Conclusion Continuous sequential therapy of femoston can effectively relieve menopausal syndrome and control the menstrual cycle and the endocrine level without stimulating the endometrium excessively .
