Configuration inversion of C-2-hydroxy in lycorine
10.3969/j.issn.1006-0111.2016.06.008
- VernacularTitle:石蒜碱2唱位羟基构型翻转的探索
- Author:
Zeng ZHAO
1
;
Xusheng XU
;
Qingyan SUN
;
Hao CHEN
;
Runhui LIU
Author Information
1. 第二军医大学药学院天然药物化学教研室
- Keywords:
lycorine;
asiaticumine B;
configuration inversion
- From:
Journal of Pharmaceutical Practice
2016;34(6):511-515
- CountryChina
- Language:Chinese
-
Abstract:
Objective Study configuration inversion of C-2-hydroxy in lycorine to provide a foundation for semi-synthesis of asiaticumine B .Methods Use instrumental analyses to explore the C-2-hydroxy configuration through oxidation and reduc-tion reactions .Results Accomplished configuration inversion of C-2-hydroxy in lycorine with 49% yield .Conclusion We identified a convenient and efficient method for the configuration inversion of C 2-hydroxy in lycorine .
