Effects of p-hydroxyacetophenone on bile secretion and blood lipid levels in rats
10.3969/j.issn.1006-0111.2016.06.007
- VernacularTitle:对羟基苯乙酮对正常大鼠胆汁分泌及高脂血症的影响
- Author:
Yifang DENG
1
;
Pengxia YU
;
Xiaoling HUANG
;
Xingdong HE
;
Ming YIN
;
Minyu LIU
Author Information
1. 中国医药工业研究总院
- Keywords:
p-hydroxyacetophenone(PHA);
artemisiae capillaries;
choleretic;
cholesterol
- From:
Journal of Pharmaceutical Practice
2016;34(6):507-510,525
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects and mechanism of p-hydroxyacetophenone (PHA ) on bile secretion ,choles-terol metabolism and blood lipids .Methods Cystic duct cannula was cannulated and bile were collected in SD rats .PHA was administrated in the high cholesterol rats .The activity of HMG-CoA reductase was determined by spectrophotometry in reac-tion system .Samples of liver were obtained in experiment hypercholesterolemia rats and Real-time PCR test was conducted for AQP8 ,CYP7A1 ,OATP and NTCP .Results Secretion of bile were increased ,cholesterol in bile were reduced and secretion of total bile acid were increased in rats by PHA .The level of serum cholesterol in hyperglycemia rat model was reduced signifi-cantly and inhibitory ability had been limited in the activity of HMG-CoA reeducates by PHA ,but the gene transcription inclu-ding AQP8 ,CYP7A1 ,OATP ,and NTCP were promoted ,which are related to function of excretion of biliary acid and trans-formation of cholesterol .Conclusion These results suggest that PHA ,as a lead compound ,might be of significance for fur-ther development for a bile secretory and lipid lowering agent .
