Progress of the drug efflux mechanisms underlying fungi multidrug resistance

VernacularTitle:真菌多药耐药外排机制的研究进展
Author: Ye KANG ¹ ; Mi ZHOU ; Lan YAN
Author Information

1. 原沈阳军区总医院北陵临床部
Keywords: fungus; multidrug resistance; multidrug efflux transporters
From: Journal of Pharmaceutical Practice 2016;34(6):485-488
CountryChina
Language:Chinese
Abstract: The multidrug resistance (MDR) ,characterized by the simultaneous acquisition of resistance to chemically and structurally different drugs ,has caused antifungal treatment failure .This review focused on recent progresses in under-standing of the multidrug resisitance associated drug efflux transporter superfamily in Saccharomyces cerevisiae ,the opportun-istic fungal pathogens Candida albicans ,Candida glabrata ,and Aspergillus fumigates ,along with the mechanisms underly-ing efflux pump and the regulatory networks involved .Investigation of these mechanisms and their impact on drug resistance may lead to strategies to overcome fungal multidrug resistance and improvement of drug efficacy .