Cystine knot peptide′s properties and its applications for drug design and molecu-lar engineering
10.3969/j.issn.1006-0111.2016.06.001
- VernacularTitle:胱氨酸结模体多肽的特征及其在药物设计和分子工程中的应用
- Author:
Yuchen DENG
1
;
Jiawei GU
;
Fei NIE
;
Liang XIAO
Author Information
1. 第二军医大学
- Keywords:
cystine knot;
cyclic cystine knot;
inhibitor cystine knot;
Kalata B1
- From:
Journal of Pharmaceutical Practice
2016;34(6):481-484,496
- CountryChina
- Language:Chinese
-
Abstract:
The cystine knot (CK) motif comprises an internal ring formed by two disulfide bonds and their connecting backbone segments which is threaded by a third disulfide bond .It is present in peptides and proteins of a variety of species ,in-cluding fungi ,plants ,marine molluscs ,insects and spiders .CK polypeptide is one of the ideal model molecules for drug design and molecular engineering research because of its stable structure and variety of bioactivities .Here we summarized the main structural features of both inhibitor cystine knot (ICK) peptide and cyclic cystine knot (CCK) peptide ,including primary se-quence ,topology ,permutation ,synthesis and folding characteristics ,as well as its applications on drug design and molecular engineering .
