Comparison of the suppressive effect of dezocine,lidocaine and ephedrine on fentanyl-induced cough
10.3969/j.issn.1006-0111.2016.05.021
- VernacularTitle:地佐辛、利多卡因、麻黄碱对芬太尼呛咳反应抑制作用的比较
- Author:
Zhi WANG
1
;
Yuanhong DONG
;
Zhenyi CHEN
Author Information
1. 厦门大学附属第一医院麻醉科
- Keywords:
fentanyl;
cough;
dezocine;
lidocaine;
ephedrine
- From:
Journal of Pharmaceutical Practice
2016;34(5):463-465
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the suppressive effect of dezocine ,lidocaine and ephedrine on fentanyl-induced cough . Methods A total of 120 patients ASA I-II ,scheduled for elective surgery under general anesthesia ,were randomly allocated into four groups (n= 30 ,each group) .Group Ⅰ ,Ⅱ ,Ⅲ ,Ⅳ were given saline (2 ml) ,dezocine (0 .1 mg/kg) ,lidocaine (1 mg/kg) or ephedrine(5 mg) ,respectively .One minute later all patients were injected with 4μg/kg of fentanyl ,after anoth-er one minute ,all patients were given midazolam (0 .1 mg/kg)+ propofol(2 mg/kg ,0 .4 ml/s)+cisatracurium (0 .2 mg/kg) . The incidence rate and severity of cough were recorded and hemodynamic parameters were also observed .Results The inci-dence rate of cough was 50% ,16 .7% ,13 .3% and 20% for group Ⅰ ,Ⅱ ,Ⅲ and Ⅳ ,respectively .Comparing to group I ,the incidence rate of cough was significantly lower (P<0 .05) in other groups ,but among the three experimental groups there was no significant difference in cough incidence rate and intensity .The hemodynamic changed of each group before and after the in-duction was consistent .Conclusion A priming dose of dezocine(0 .1 mg/kg) ,lidocaine (1 mg/kg) or ephedrine (5 mg) could effectively reduce the Fentanyl-induced cough response .
