Study of optimization for the cream base of benzhydramine hydroehloride
10.3969/j.issn.1006-0111.2016.05.019
- VernacularTitle:盐酸苯海拉明乳膏的基质优选研究
- Author:
Huayan SUN
1
;
Fenghua XU
;
Jie LI
;
Lin BAI
;
Le CAI
Author Information
1. 解放军总医院 制剂室
- Keywords:
benzhydramine hydroehloride cream;
base formula;
quality control
- From:
Journal of Pharmaceutical Practice
2016;34(5):455-458
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the cream base of benzhydramine hydroehloride .Methods Five nonionic surfactants as an emulsifier were used to prepare benzhydramine hydroehloride creams .The five sorts of cream were evaluated from the ap-pearance ,preliminary stability ,accelerated test stability and room temperature stability .Results Benzhydramine hydroehloride cream could be prepared using five nonionic surfactants .On appearance of smoothness ,gloss and spread ,formula E was best but formula A was worst ,while formulas B and D were close and worse than formula E only .In the stability tests ,all of creams had no obvious change after the centrifugal experiment and the low temperature experiment .In the high temperature ex-periment ,the formula E was stable ,formulas A ,B and D showed a little appearance change ,and the formula C became layered bleeding .In room temperature ,the formula C became bleeding after five days ,which happened to the formula A after one month ,and formula B after two months .The formulas D and E had no obvious change until six months in room temperature . Conclusion The formulas D and E were stable ,which had clinical application value .
