The evaluation and analysis on the results of voriconazole plasma concentration monitoring
10.3969/j.issn.1006-0111.2016.05.010
- VernacularTitle:伏立康唑血药浓度监测结果评析
- Author:
Miao YAN
1
;
Ningning WANG
;
Ziwei LI
;
Mengfei JIANG
;
Feng WANG
;
Bikui ZHANG
;
Ping XU
;
En Yi-w XIAO
Author Information
1. 中南大学湘雅二医院药学部
- Keywords:
voriconazole;
TDM;
renal transplantation department;
infectious disease department
- From:
Journal of Pharmaceutical Practice
2016;34(5):421-423,446
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clarify the necessity of therapeutic drug monitoring (TDM ) of voriconazole ,and give relevant clinical tips ,by comparing the plasma concentration of different clinical specialties before and after adjustment of dose .Methods This is a retrospective study of voriconazole TDM data .It involves 435 cases voriconazole plasma trough concentration meas-urement results of 154 inpatients to make a preliminary assessment .Results 4 .3% plasma concentration were higher than 5 .5 μg/ml ,26 .5% plasma concentration were less than 1 .0 μg/ml in renal transplantation department ;while 52 .3% plasma concentration were higher than 5 .5 μg/ml ,no less than 1 .0 μg/ml in infectious disease department .Conclusions Therapeutic drug monitoring is necessary for rational use of voriconazole .The majority of plasma concentrations in renal transplantation pa-tients were <1 .0 μg/ml ,lower than recommended treatment concentration range ;while most infectious disease patients have> 5 .5 μg/ml ,higher than recommended treatment concentration range .Clinical pharmacists can be more closely involved in the clinical use of voriconazole based on the results of the therapeutic drug monitoring .
