Experimental study on the effects of Yangxinshi tablets in the prevention and treatment of chronic ischemic heart failure and acute myocardial ischemia reper-fusion injury
10.3969/j.issn.1006-0111.2016.05.006
- VernacularTitle:养心氏片防治慢性缺血性心力衰竭及急性心肌缺血再灌注损伤的实验研究
- Author:
Yue GAO
1
;
Anni CHEN
;
Yahong ZHAO
;
Dan XUE
;
Yongtong AN
;
Yifeng CHAI
;
Hai ZHANG
Author Information
1. 第二军医大学药学院实验教学中心
- Keywords:
Yangxinshi tablet;
chronic ischemic heart failure;
acute myocardial ischemia reperfusion
- From:
Journal of Pharmaceutical Practice
2016;34(5):403-407,415
- CountryChina
- Language:Chinese
-
Abstract:
Objective Experimental study on effects of Yangxinshi tablets in the prevention and treatment of chronic is-chemic heart failure and acute myocardial ischemia reperfusion injury in order to provide a theoretical basis for its clinical appli-cation .Method Rat model of chronic ischemic heart failure and acute ischemia reperfusion mouse model of myocardial infarc-tion were constructed through coronary artery ligation .Those animals were randomized to sham operation group ,model group , positive drug group ,high Yangxinshi tablet dose group ,middle Yangxinshi tablet dose group ,low Yangxinshi tablet dose group .Rat electrocardiogram ,ultrasound ,ACE ,ACD ,TNF-a ,mouse myocardial infarction area ,CK ,LDH ,SOD and relat-ed factors were recorded during pre-dosing and post-dosing after modeling .Morphological changes were observed with cardiac pathological section .Results The biochemical indicators in model group were significantly different from sham operation group with statistical significance (P<0 .001) .Compared to the model group ,positive drug group and high Yangxinshi tablet dose group exhibited biochemical differences with statistical significance (P<0 .001 ,P<0 .01 ,P<0 .05) ,significant myocardial in-farction area reduction (P<0 .01 ,P<0 .05) ,improvement in myocardial cells and reduction in the cell infiltration .Conclusion Yangxinshi tablets have preventive and therapeutic effects on chronic ischemic heart failure and acute ischemia reperfusion in-jury .
