Effect of the curcumin on expression of IL-2 and IL-6 of hippocampus in pentyle-netetrazol-induced epilepsy in rats
10.3969/j.issn.1006-0111.2016.04.018
- VernacularTitle:姜黄素对戊四氮致癫大鼠海马区 IL-2和IL-6表达水平的影响
- Author:
Wei DONG
1
;
Jianwei YAN
;
Qiaoling TAN
;
Sen YE
Author Information
1. 余姚市人民医院
- Keywords:
curcumin;
epilepsy;
IL-2;
IL-6
- From:
Journal of Pharmaceutical Practice
2016;34(4):354-356
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of anti-epileptic effect of the curcumin .Methods The SD rats were injected intraperitoneally with pentylenetetrazol kindling 25 .0 mg/kg to induce a rat epilepsy model .All of the treatments were performed once a day continuously for 28 days .The rats in blank group and model group received 5 ml of normal saline .The rats in the high and low curcumin group were given 200 mg/kg and 100 mg/kg of curcumin once a day ,respectively .The rats in the sodium valproate (VPA) group were given 400 mg/kg of VPA once a day by gavage .After treatment ,the seizures level was recorded by using the Racine′s six point grading scale ,and the expression of IL-2 and IL-6 of hippocampus were detected by the enzyme linked immunoassay (ELISA) .Results The seizures level was reduced by curcumin in epileptic rats .The ex-pressions of IL-2 and IL-6 of the model group were significantly higher than those of the blank group (P<0 .05) ,while those rats of the anti-epileptic groups ,including high dose group and low dose group ,were lower than those rats of the model group (P<0 .05) .When compared with the curcumin low dose group ,the expression of IL-2 and IL-6 of curcumin high dose group is lower (P< 0 .05) .There was no significant difference between the high dose curcumin group and VPA group (P>0 .05) . Conclusion The curcumin can reduce the seizure level in rats ,it shows some anti-epileptic effets and dose-dependently ,which may be through down-regulating the expression of IL-2 and IL-6 in hippocampus .
