Study on quality control of Minuo Hair Solution
10.3969/j.issn.1006-0111.2016.04.015
- VernacularTitle:米诺生发搽剂的质量标准研究
- Author:
Linping YAN
1
;
Lingling BAI
;
Jing HUANG
;
Ting WANG
;
Hua SU
;
Xin LIAO
Author Information
1. 南京军区南京总医院制剂科
- Keywords:
Minuo Hair Solution;
minoxidil;
Angelica sinensis;
Paeoniae Radix Rubra;
Dictamni Cortex;
quality standard
- From:
Journal of Pharmaceutical Practice
2016;34(4):343-347
- CountryChina
- Language:Chinese
-
Abstract:
Objective To improve the quality standard of Minuo Hair Solution and to ensure product quality .Methods Thin layer chromatography (TLC) and UV-visible spectroscopy (UV-Vis) method was used for the qualitative identification of Angelicasinensis ,Paeoniae Radix Rubra ,Dictamni Cortex and minoxidil respectively .The Quantitive determination of mi-noxidil was completed by first order derivative spectroscopy .Results The spots in TLC were clear without inference .And the same color spots appeared in the corresponding position of references and reference drugs .The UV-Vis spectral absorption of minoxidil were in (230 ± 3) ,(262 ± 3) ,(286 ± 3) nm .The linear range of minoxidil was obtained between 6 .2 and 18 .6 μg/ml (r=0 .999 7) .The average recovery was 99 .4% (RSD=0 .22% ) .Conclusion The method is simple ,accurate and reproduci-ble ,and can be effectively used to control the quality of Minuo Hair Solution .
