Synthesis and antifungal activities of novel triazole derivatives containing sulfur atoms

VernacularTitle:含硫的三唑类化合物的合成及抗真菌活性研究
Author: Zhiqiang ZHANG ¹ ; Ben FU ; Baogang WANG ; Chao ZHANG ; Wanqing LIAO ; Weihua PAN ; Zhongwu GUO
Author Information

1. 第二军医大学药学院有机化学教研室
Keywords: triazole; synthesis; antifungal activities
From: Journal of Pharmaceutical Practice 2016;34(4):334-337
CountryChina
Language:Chinese
Abstract: Objective To design and synthesis novel triazole antifungal derivatives with dithiocarbamates side chain and study the antifungal activities .Methods Nine title compounds were synthesized and characterized by 1 H NMR ,MS spectra . The in vitro antifungal activities of all the compounds were evaluated against eight human pathogenic fungi .Results The title compounds exhibited strong antifungal activities .Some compounds showed excellent activities against Candida albicans with the MIC80 values less than 0 .125 g/ml ,6d was 64 times higher than that of Itraconazole .Conclusion The introduction of the propyl ,sulphur and benzyl moiety to the side chain could affect the antifungal activities .