The preparation of self-microemulsifying dropping pills of paclitaxel and its drug release in vitro
10.3969/j.issn.1006-0111.2016.04.012
- VernacularTitle:紫杉醇自微乳滴丸的制备及体外释放考察
- Author:
Kexing WANG
1
;
Cuiying QIN
;
Jing HAN
;
Rongli LI
;
Rencai CHEN
Author Information
1. 沈阳药科大学
- Keywords:
paclitaxel;
self-microemulsifying;
dropping pills;
orthogonal test;
cumulative release
- From:
Journal of Pharmaceutical Practice
2016;34(4):330-333
- CountryChina
- Language:Chinese
-
Abstract:
Objective The research is about optimization of preparation procedure of self-microemulsifying dropping pills of paclitaxel (PTX-SM-DP) .The drug release in vitro of PTX-SM-DP was investigated .Methods The ratio of SMEDDS and bases ,dropping distance ,temperature and speed of dripping were investigated by using the orthogonal test .The weight differ-ence of dropping pill ,hardness and roundness were evaluated to optimize the preparation conditions of PTX-SM-DP .Dissolu-tion of vitro was determined .Results The optimal preparation conditions were as follows :the ratio of SMEDDS and bases was 1∶3 ,dropping distance was 15 cm ,temperature of dripping preparation was 80 ℃ and dripping speed was 30 drops/min . Conclusion The optimized technical condition is stable and feasible .PTX-SM-DP can improve paclitaxel dissolution .
