Experimental study on physical dependence of total Ervatamia yunnansis alkaloid
10.3969/j.issn.1006-0111.2016.04.011
- VernacularTitle:狗牙花总生物碱的身体依赖性实验研究
- Author:
Zhiyuan LI
1
;
Xiaodong ZHANG
;
Xinhong WANG
;
Duo ZHOU
Author Information
1. 解放军22医院
- Keywords:
total Ervatamia yunnansis alkaloid;
physical dependence;
morphine
- From:
Journal of Pharmaceutical Practice
2016;34(4):327-329
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the physical dependence of total Ervatamia yunnansis alkaloid .Methods The physi-cal dependence of total Ervatamia yunnansis alkaloid was observed by jump test in mice and spontaneous withdrawal test in rats .Results In the jump test ,after injecting total Ervatamia yunnansis alkaloid (total dosage of 140 and 430 mg/kg) for 7 days continuously ,the mice didn't show any withdrawal symptom and the loss of body weight .In the spontaneous withdrawal test ,two dosages of total Ervatamia yunnansis alkaloid (total dosage of 210 and 775 mg/kg) were continuously given for 30 days .The withdrawal response and the loss of body weight were not found in rats after drug withdrawal .Conclusion Total Ervatamia yunnansis alkaloid showed no obvious withdrawal symptoms in mice and rats ,which suggests that it has no physical dependence .
