Research progress on animal model and potential therapeutic strategy in intracere-bral hemo rrhage
10.3969/j.issn.1006-0111.2016.04.003
- VernacularTitle:脑出血损伤的动物模型及治疗策略的研究进展
- Author:
Chunchun WEI
1
;
Pei WANG
;
Chaoyu MIAO
Author Information
1. 第二军医大学药学院药理学教研室
- Keywords:
intracerebral hemorrhage(ICH);
animal model;
neuroinflammation;
stem cell therapy
- From:
Journal of Pharmaceutical Practice
2016;34(4):297-300,376
- CountryChina
- Language:Chinese
-
Abstract:
Intracerebral hemorrhage (ICH) refers to bleeding within the brain parenchyma due to the rupture of blood vessels ,and is a highly lethal stroke subtype ,accounting for nearly 10%-15% of all strokes .The morbidity and mortality of ICH are very high and its pathophysiological mechanisms are currently not fully understood .Therefore ,based on current clini-cal evidence-based medicine ,there is no definite and effective medical treatment that can improve the prognosis and survival of patients available yet .As an important tool for basic research ,the development and application of the ICH animal model pro-moted the understanding of the pathophysiological mechanisms and molecular mechanisms leading to brain injury by ICH .Re-cently ,the ICH animal model studies contributed to a number of proposed potential therapeutic strategies ,such as the inhibi-tion of thrombin and the reduction of pro-inflammatory pathways .In addition ,recent research of stem cells suggested that cell transplantation therapy for the treatment of ICH may also have good prospects .In this review ,we discuss the development and application of animal models for studies on ICH and the advances regarding the potential therapeutic strategies for ICH .
