Research progress on hepatoprotective effects of Erzhiwan and its components
10.3969/j.issn.1006-0111.2016.04.001
- VernacularTitle:二至丸及其组成药味保肝药理作用研究进展
- Author:
Dongmei HU
1
;
Xiaoling CHEN
;
Yang LU
;
Minfeng FANG
;
Jingwen WANG
;
Aidong WEN
Author Information
1. 第四军医大学附属西京医院药剂科
- Keywords:
Erzhiwan;
Ligustri Lucidi Fructus;
Herba Ecliptae;
hepatic injury;
hepatoprotective effect
- From:
Journal of Pharmaceutical Practice
2016;34(4):289-291,296
- CountryChina
- Language:Chinese
-
Abstract:
Erzhiwan includes two components of Chinese herbal medicines - Ligustri Lucidi Fructus and Herba Eclip-tae .Ligustri Lucidi Fructus ,Herba Ecliptae and their formulation have various hepatoprotective effects .There are many ac-tive ingredients in the formulation ,such as triterpenes ,iridoids ,phenethyl alcohol-glucosides ,coumarin ethers ,etc .They can resist various chemistry-induced hepatic injury ,ischemia reperfusion induced hepatic injury ,and hepatic fibrosis .The mecha-nisms of hepatoprotective effect include anti-oxidative stress ,anti-inflammatory ,inhibition of hyperplasia and activation of liver stellate cell ,motivating the apoptosis of liver stellate cell ,influencing the metabolic processes of liver cell ,ect .We reviewed and summarized the hepatoprotective effects of Erzhiwan and its components Ligustri Lucidi Fructus and Herba Ecliptae and explore the mechanisms of hepatoprotective effect in order to provide information for further research of pharmacodynamic ma-terial base .
