Quality of control of compound chlorhexidine acetate ointment
10.3969/j.issn.1006-0111.2016.03.017
- VernacularTitle:复方醋酸氯己定软膏质量标准研究
- Author:
Wenjun HU
1
;
Zhaohui DENG
;
Aihong LI
;
Wei CI
Author Information
1. 广州军区联勤部药品仪器检验所
- Keywords:
compound chlorhexidine acetate ointment;
TLC;
HPLC
- From:
Journal of Pharmaceutical Practice
2016;34(3):258-260,266
- CountryChina
- Language:Chinese
-
Abstract:
Objective To improve the standard of the quality control of compound chlorhexidine acetate ointment . Methods TLC was used to control the quality of menthol crystal and camphor .A method to determine chlorhexidine acetate and cocaine hydrochloride simultaneously by HPLC was established .Results The spots of menthol crystal and camphor in TLC were clear .Chlorhexidine acetate and cocaine hydrochloride showed excellent linearity ,which were at the range of 10.01-160.14 μg/ml and 10 .01-160 .14 μg/ml ,respectively .The average recoveries were 101 .5% (RSD=1 .8% ) and 100 .5% (RSD=2 .8% ) .Conclusion The methods were simple ,sensitive and with good reproducibility and could be used to control the quality of compound chlorhexidine acetate ointment .
