Discussion on the purified water inspection methods in the Chinese Pharmacopoeia of edition 2010
10.3969/j.issn.1006-0111.2016.03.015
- VernacularTitle:浅谈2010年版《中华人民共和国药典》纯化水检查方法的完善
- Author:
Qiang LIU
1
;
Zhiguo SUN
;
Yi CHEN
;
Qi CHEN
;
Hualin HUANG
;
Jing GAO
Author Information
1. 第二军医大学药学院
- Keywords:
purified water;
nitrate;
nitrite;
ammonia;
instrumental analysis
- From:
Journal of Pharmaceutical Practice
2016;34(3):252-254
- CountryChina
- Language:Chinese
-
Abstract:
Objective To modify the purified water analysis methods in the Chinese Pharmacopoeia (Vol .Ⅱ ,Edition 2010) ,and mainly focus on the pH value determination ,analysis of nitrate and nitrite ,and the inspection of microorganism . Methods The usage of regents and colorimetric tubes in the analysis of nitrate and nitrite were inquired ,the feasibility of plat-ing culture used in the inspection of microorganism were proposed ,and the suggestion of using more instrumental analysis in-stead of titrimetric analysis in the purified water inspection wasraised .Results The choice of colormetric apparatus and the precision of the regents were explicit .The plating method was better in convenience and reliability than membrane-filter proce-dure during the microorganism inspection .Instrumental analysis is the trend of purified water inspection and deserved to be rec-ommended .Conclusion Based on our own and others′studies ,the methods of impurity analysis are improved ,which might be accepted in the revision of Chinese Pharmacopoeia in future .
