Study of total celosins on liver protection in different liver damage model
10.3969/j.issn.1006-0111.2016.03.003
- VernacularTitle:青葙总皂苷对肝损伤保护作用的研究
- Author:
Ying TANG
1
;
Lin LIANG
;
Meili GUO
Author Information
1. 福建中医药大学药学院
- Keywords:
Celosiae Semen;
total celosins (CES);
liver damage;
hepatoprotection
- From:
Journal of Pharmaceutical Practice
2016;34(3):201-205,282
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the liver protection of total celosins (CES) in different liver damage models .Method A-cute liver damage mouse model ,chronic liver damage rat model and immune liver damage mouse model were established for this study .Liver function tests ,liver lipid peroxidation indicators and liver pathology were observed .Results CES of each dose group can lower serum ALT and AST in different degrees ,can significantly reduce the content of MDA in liver homogenate , while can increase SOD activity .Pathological examination showed that animals administered significantly reduced the degree of liver cell damage .Conclusion CES have protective effects on acute liver damage induced by CCl 4 ,chronic liver damage induced by CCl4 and immunological liver damage induced by concanavalin A .Its hepatoprotective effect may be related to its antioxidant effects .
