Orthogonal design optimization in synthesis of novel triazole antifungal com-pounds as key intermediates
10.3969/j.issn.1006-0111.2016.02.018
- VernacularTitle:正交设计法优化新型氮唑类抗真菌化合物关键中间体的合成工艺
- Author:
Junqi WU
1
;
Xiaofei YE
;
Lei HUANG
;
Xiaoyun CHAI
;
Yongsheng JIN
;
Shichong YU
Author Information
1. 第二军医大学
- Keywords:
orthogonal experimental design;
triazole compounds;
antifungal;
synthesis
- From:
Journal of Pharmaceutical Practice
2016;34(2):171-173
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize novel triazole antifungal compounds synthesis of key intermediates.Methods The or-thogonal experimental design is used,emphasizing on four factors including the reaction temperature,the weight ratio of mate-rial,reaction time and solvent on the yield.Results The effect of reaction temperature on the reaction yield is the most signifi-cant,followed by reaction time ;the weight ratio of material and solvent on the yield impact is not obvious.Conclusion The new technology has several advantages and yields up to about 50%,less reactive impurities,easy post processing.
