Preparation of paeoniflorin gastric floating tablets
10.3969/j.issn.1006-0111.2016.02.014
- VernacularTitle:芍药苷胃漂浮片的制备
- Author:
Jiali JIA
1
;
Yueying HUANG
;
Jun BIAN
Author Information
1. 解放军411医院药学科
- Keywords:
paeoniflorin;
gastric floating tablet;
cumulative release rate in vitro
- From:
Journal of Pharmaceutical Practice
2016;34(2):153-157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare paeoniflorin gastric floating tablets and to optimize the formulation.Methods Gastric floating tablets were prepared by wet granulation,with floating performance and in vitro cumulative release rate as evaluat indi-cators,single factor tests and orthogonal design test were adopted for the optimal formulation.Results With HPMC K4M 20% as reinforcing materials,NaHCO315% as gas agent,PVPP 7% as the release of accelerator,lactose as a filler,the ob-tained gastric floating tablet can immediately play bleaching,continued to float more than 12 hours,and the cumulative release rate was more than 90%.Conclusion The optimal formulation of paeconiflorin floating tablet has achieved a sustained and slow release request floating,the operability is good.
