Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa
10.3969/j.issn.1006-0111.2016.02.011
- VernacularTitle:南海棘体海绵Acanthella cavernosa中的化学成分分析
- Author:
Wei FAN
1
;
Xudong WANG
;
Haimin CAI
;
Liguang SUN
;
Ling YANG
;
Suifeng NIE
Author Information
1. 解放军425医院
- Keywords:
sponge;
chemical constituents;
structure identification
- From:
Journal of Pharmaceutical Practice
2016;34(2):138-141,166
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the secondary metabolites of the South China Sea spine body sponge Acanthella cavernosa.Methods The acetone extract of A.cavernosa was isolated and purified by repeated column chromatography on sili-ca gel,sephadex LH-20,and high-performance liquid chromatography (HPLC).Structures were determined by spectroscopic analysis and comparison with reported data.Results Nine compounds were isolated.Their structures were determined as kali-hinol E (1),kalihinol A (2),10-epi-kalihinol X (3),10-epi-kalihinol I (4),1 H-indole-3-carboxylic acid methyl ester (5), 1H-indole-3-carboxylic acid (6),3-buten-2-one,4-(2,3,6-trimethylphenyl)-(3E)(7),aristolone (8),and 5α,8α-epidioxy-(22E,24R)-erost-6,22-dien-3β-ol (9).Conclusion Compounds 5 to 8 were isolated from the sponge of genus Acanthalla for the first time.
