Optimization of synthesis process of photosensitizer chlorin f
10.3969/j.issn.1006-0111.2016.02.010
- VernacularTitle:光敏剂二氢卟吩f的合成工艺优化
- Author:
Guiyan HAN
1
;
Zhi MENG
;
Minghui LIU
;
Junhong LIU
;
Chunquan SHENG
;
Jianzhong YAO
Author Information
1. 第二军医大学药学院,上海,200433
- Keywords:
photosensitizer;
chlorin f;
orthogonal experimental design;
process improvement
- From:
Journal of Pharmaceutical Practice
2016;34(2):135-137
- CountryChina
- Language:Chinese
-
Abstract:
Objective To improve the synthesis process of chlorine f (1).Methods A "one-pot"method was applied to prepare Photosensitizer component (1),using pheophorbide a (3) as raw material by oxidating and cracking of the E-ring of (3) with bubbling oxygen in alcoholic solution of potassium hydroxide at 0 ℃ followed by refluxing in nitrogen atmosphere.In order to obtain the optimal synthetic procedure,the orthogonal experimental design of L9 (34 ) was adopted to investigate three different levels of four main factors i.e.ring opening reaction time,alcoholic variety,alkali concentration and refluxing reaction time.Results The target compound (1) was optimizedly synthesized through treatment of raw material (3) with bubbling oxy-gen in 25% ethanol solution of potassium hydroxide at 0℃ for 30 min,followed by refluxing in nitrogen atmosphere for 20 min in yield of 40.8%.Conclusion The procedure developed has some advantages of simple and safty operation,and high synthetic yield.
