Advances on the research of the pharmacological activity mechanism and toxicolo-gy of Glaucocalyxin A
10.3969/j.issn.1006-0111.2016.02.008
- VernacularTitle:蓝萼甲素的药理活性及其机制和毒理作用的研究进展
- Author:
Qingqing CHI
1
;
Qiang WANG
;
Yanqiang ZHONG
Author Information
1. 大连医科大学
- Keywords:
Glaucocalyxin A;
Rabdosia (BI.) Hassk;
pharmacological activity;
toxicology
- From:
Journal of Pharmaceutical Practice
2016;34(2):124-128
- CountryChina
- Language:Chinese
-
Abstract:
Glaucocalyxin A (GLA) is a kind of diterpenoid enantiomers with organic chemical structure of en-15-oxo-16-kaurene.It has various pharmacological activities,such as cardiovascular and endothelium cellular protection,anti-blood coagu-lation,anti-Hepatitis B Virus (HBV),anti-tumor,anti-bacteria,anti-inflammation,hypoxic tolerance,immunomodulation and Ca2+ concentration regulation effect,where as its in vivo safety is quite good.As a folk medicine,it is conventionally used to treat hepatitis,gastritis,mastitis,stomachache and arthralgia.It is also used for ischemic and/or hypoxic cardio-cerebrovas-cular diseases such as coronary heart diseases,stenocardia and chronic cerebral circulation insufficiency in clinic.This review gives a summary of the pharmacological effects,biological mechanism,and toxicity of Glaucocalyxin A.
