Research progress of structural modification of oridonin
10.3969/j.issn.1006-0111.2016.02.005
- VernacularTitle:冬凌草甲素的结构修饰研究进展
- Author:
Hongchuan LIU
1
;
Yongsheng JIN
;
Haisheng CHEN
Author Information
1. 首都医科大学附属北京朝阳医院药事部
- Keywords:
oridonin;
Labtea;
structure modification;
diterpene
- From:
Journal of Pharmaceutical Practice
2016;34(2):114-115,134
- CountryChina
- Language:Chinese
-
Abstract:
Oridonin is an en-kaurene diterpenoids compound which was found to have effect on tumor in vitro.But the clinical application has been limited because of poor water solubility,low bioavailability and oral absorption.Many scholars conducted a large number of structure modification researches of oridonin to search for new diterpenes with higher bio-activities and better bio-availabilities,and to develop new antitumor drugs.In this paper,studies on this aspect of oridonin were re-viewed.
