Research progress of fluconazole derivatives
10.3969/j.issn.1006-0111.2016.02.004
- VernacularTitle:氟康唑类似物的研究进展
- Author:
Kehan XU
1
;
Lei HUANG
;
Junqi WU
;
Lin QI
;
Yongsheng JIN
;
Shichong YU
Author Information
1. 第二军医大学药学院有机化学教研室
- Keywords:
fluconazole;
antifungal agents;
structural modification;
synthesis
- From:
Journal of Pharmaceutical Practice
2016;34(2):110-113,128
- CountryChina
- Language:Chinese
-
Abstract:
Fluconazole,the third generation of triazole-antifungal drug,becomes the first choice in the treatment of fun-gal infection due to its broad antifungal spectrum,good water solubility and low toxicity.With an increasingly drug-resistant strain,developing new fluconazole derivatives is becoming an attractive topic.This review mainly indicates that people can get new fluconazole derivatives used by clinic through structural modification of fluconazole,which will give clues for advanced re-search.