Advances of validation of bioactive small molecule targets
10.3969/j.issn.1006-0111.2016.02.001
- VernacularTitle:活性小分子化合物靶点验证方法的研究进展
- Author:
Shuqiang CHEN
1
;
Guoqiang DONG
;
Chunquan SHENG
;
Wannian ZHANG
Author Information
1. 第二军医大学药学院
- Keywords:
pulldown;
small molecule drugs;
target identification;
fluorescent probes
- From:
Journal of Pharmaceutical Practice
2016;34(2):97-102
- CountryChina
- Language:Chinese
-
Abstract:
With the development of science and the progress of age,medicinal chemistry is not only limited to the lead discovery and the structure-activity relationship studies,but also finding the target of bioactive small molecule drugs has be-come a tough issue to be solved.The identification and validation of bioactive small molecule targets has become the most criti-cal and difficult task,which plays a decisive role in academic and pharmaceutical research.Herein we summarize the current methods for target identification of small molecules,and mainly discuss about the target identification method by the chemical probes.Recent cases of successful application were also introduced to demonstrate the strategy of probe synthesis and design.
