Meta-analysis on treatment of lower respiratory tract infection of azatreonam or ceftazidime

VernacularTitle:氨曲南与头孢他啶治疗下呼吸道感染的荟萃分析
Author: Siwei BAO ¹ ; Yuyi ZHANG ; Yanming HU ; Xiaobo ZHAI ; Zhigao HE
Author Information

1. 同济大学附属东方医院药学部
Keywords: lower respiratory tract infection; azatreonam; ceftazidime; Mata-analysis
From: Journal of Pharmaceutical Practice 2016;(1):83-85,89
CountryChina
Language:Chinese
Abstract: Objective The aim of the study is to evaluate clinical efficacy and safety of azatreonam or ceftazidime on treatment of lower respiratory tract infection .Methods Four English databases (MEDLINE、EMBASE、Pubmed、Cochrane li‐brary) and three Chinese databases (CNKI、VIP、WANFANG) were searched .Meta‐analysis was performed using Review Manager 5 .2 .Results The Meta‐analysis revealed azatreonam was superior to ceftazidime in total efficiency (RR=1 .15 ,95%CI is 1 .09‐1 .21) .No significant differences are seen between azatreonam and ceftazidime (RR=1 .03 ,95% CI is 0 .98‐1 .09) on the bacterial eradication rates or the incidence of adverse reactions (RR=0 .66 ,95% CI is 0 .39‐1 .12) .Conclusion Azatreonam is more effective than ceftazidime on the treatment of lower respiratory tract infection in the clinical practice .